Osbert Zalay, Dennis Bontempi, Danielle S Bitterman, Nicolai Birkbak, Derek Shyr, Fridolin Haugg, Jack M Qian, Hannah Roberts, Subha Perni, Vasco Prudente, Suraj Pai, Andre Dekker, Benjamin Haibe-Kains, Christian Guthier, Tracy Balboni, Laura Warren, Monica Krishan, Benjamin H Kann, Charles Swanton, Dirk De Ruysscher, Raymond H Mak, Hugo JWL Aerts

FaceAge, a deep learning system, estimates biological age from facial photographs, trained on 58,851 individuals and validated on 6,196 cancer patients. It proved prognostically relevant, showing cancer patients typically appear older than their chronological age, correlating with worse survival. FaceAge enhances end-of-life predictions for palliative care patients and is linked to molecular senescence mechanisms, demonstrating its potential in clinical decision-making beyond cancer.

Daniel P. Windred, Angus C. Burns, Jacqueline M. Lane, Patrick Olivier, Martin K. Rutter, Richa Saxena, Andrew J. K. Phillips, Sean W. Cain

Exposure to bright light at night, recorded in over 88,000 participants, is linked to higher mortality risk over six years. Disrupted circadian rhythms, indicated by computational modeling, may explain this risk. Minimizing night light exposure and maintaining regular light-dark patterns could promote health and longevity.

Qinghao Yu, Hannah E. Walters, Giovanni Pasquini, Sumeet Pal Singh, Martina Lachnit, Catarina Oliveira, Daniel León-Periñán, Andreas Petzold, Preethi Kesavan, Cristina Subiran, Ines Garteizgogeascoa, Dunja Knapp, Anne Wagner, Andrea Bernardos, María Alfonso, Gayathri Nadar, Alwin M. Graf, Konstantin E. Troyanovskiy, Andreas Dahl, Volker Busskamp, Ramón Martínez-Máñez, Maximina H. Yun

Cellular senescence in axolotl limb regeneration promotes progenitor cell growth and blastema development via Wnt pathway modulation, as revealed by gain- and loss-of-function studies. This senescence creates a pro-proliferative environment, preventing neighboring cells from becoming senescent.

Alessandra Tammaro, Eileen G. Daniels, Iman M. Hu, Kelly C. ‘t Hart, Kim Reid, Rio P. Juni, Loes M. Butter, Goutham Vasam, Rashmi Kamble, Aldo Jongejan, Richard I. Aviv, Joris J.T.H. Roelofs, Eleonora Aronica, Reinier A. Boon, Keir J. Menzies, Riekelt H. Houtkooper, Georges E. Janssens

The study identifies a small molecule, Cmpd60, that mimics genetic longevity interventions by inhibiting HDAC1/2. It rejuvenates multiple organs, including kidneys, brain, and heart, and shows promise for healthy aging treatments.

Jennifer M. Polinski, Kate R. Castellano, Katherine M. Buckley, Andrea G. Bodnar

The genome of the long-lived red sea urchin was analyzed and compared with short-lived species, revealing chromosome rearrangements and expanded gene families linked to immunity, nervous system, and genome stability. Genes under positive selection related to genomic regulation, protein homeostasis, and mitochondrial function suggest mechanisms for maintaining tissue homeostasis, disease resistance, and negligible aging.