Olga Spiridonova, Dmitrii Kriukov, Nikolai Nemirovich-Danchenko, Leonid Peshkin

Aging intervention research, involving model organisms like mice and flies, frequently lacks consistent standards and full experimental disclosure, leading to incomparable and incoherent longevity studies. The field could benefit from systematic re-analysis and improved quality control by ensuring consistency in lifespan data.

Steve Horvath, Kavita Singh, Ken Raj, Shraddha Khairnar, Akshay Sanghavi, Agnivesh Shrivastava, Joseph A. Zoller, Caesar Z. Li, Claudia B. Herenu, Martina Canatelli-Mallat, Marianne Lehmann, Siniša Habazin, Mislav Novokmet, Frano Vučković, Leah C. Solberg Woods, Angel Garcia Martinez, Tengfei Wang, Priscila Chiavellini, Andrew J. Levine, Hao Chen, Robert T Brooke, Juozas Gordevicius, Gordan Lauc, Rodolfo G. Goya, Harold L. Katcher

Young porcine plasma treatment significantly reverses aging in rats at the epigenetic level, as shown by validated epigenetic clocks for various tissues. The treatment notably reduced the epigenetic ages of blood, heart, liver, and hypothalamus, improved organ function, and shifted IgG N-glycosylation patterns from pro- to anti-inflammatory, indicating a reversal of glycan aging.

Lora E. Liharska, You Jeong Park, Kimia Ziafat, Lillian Wilkins, Hannah Silk, Lisa M. Linares, Ryan C. Thompson, Eric Vornholt, Brendan Sullivan, Vanessa Cohen, Prashant Kota, Claudia Feng, Esther Cheng, Jessica S. Johnson, Marysia-Kolbe Rieder, Jia Huang, Joseph Scarpa, Jairo Polanco, Emily Moya, Alice Hashemi, Matthew A. Levin, Girish N. Nadkarni, Robert Sebra, John Crary, Eric E. Schadt, Noam D. Beckmann, Brian H. Kopell, Alexander W. Charney

Gene expression in postmortem human brain tissue differs significantly from that in living tissue, challenging assumptions used in medical research. This discrepancy, not explained by factors like age or medication, suggests postmortem studies may inaccurately represent brain gene expression in life, limiting their usefulness for understanding brain health and disease. Future research should consider these differences for more accurate insights.

Wei I. Jiang, Henry De Belly, Bingying Wang, Andrew Wong, Minseo Kim, Fiona Oh, Jason DeGeorge, Xinya Huang, Shouhong Guang, Orion D. Weiner, Dengke K. Ma

Early-life thermal stress in C. elegans leads to lasting up-regulation of the tsp-1 gene, crucial for membrane functions and resilience. This effect, requiring the CBP-1 enzyme, results in enhanced longevity and thermal resilience, demonstrating how early stress has long-term impacts.

Raghav Sehgal, Margarita Meer, Aladdin H. Shadyab, Ramon Casanova, JoAnn E. Manson, Parveen Bhatti, Eileen M. Crimmins, Themistocles L. Assimes, Eric A. Whitsel, Albert T. Higgins-Chen, Morgan Levine

A novel epigenetic clock, using blood-based methylation data, assesses aging in 11 specific systems (Heart, Lung, Kidney, etc.), outperforming global measures in predicting system-specific outcomes. This approach identifies unique aging subtypes and may aid in personalized age-related healthcare.