![Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice](https://cdn.prod.website-files.com/63a2ca4dc31fc6d1656daa46/64a3d660212f505d82cc9c9f_Gene%20Therapy%20In%20Mice%202x.jpg)
Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice
Lifespan of aged mice was extended through systemic delivery of AAVs encoding an OSK system. The mice, at 124 weeks old, experienced a remarkable 109% increase in median remaining lifespan compared to wild-type controls. This intervention also improved various health parameters and frailty scores, suggesting the potential to enhance both lifespan and healthspan in aging individuals. Furthermore, significant epigenetic markers of age-reversal were observed in human keratinocytes expressing exogenous OSK, indicating the possibility of reversing age-related changes. These findings have significant implications for developing interventions to combat age-associated diseases in the elderly.