Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
Exceptionally stable proteins and macromolecules are discovered in mammalian ovaries and oocytes, essential for reproductive health across the lifespan. These long-lived molecules are linked to both the maintenance and age-related deterioration of reproductive tissues.
Q4 2023Chronically disrupted sleep induces senescence in the visceral adipose tissue of C57BL/6 mice
Disrupted sleep is linked to accelerated aging, demonstrating that lack of sleep causes cellular senescence in mice's adipose tissue, leading to oxidative stress and DNA damage. Poor sleep quality may accelerate aging and increase the risk of age-related diseases by promoting senescence in adipose tissue.
Q4 2023Unlocking cellular plasticity: Enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation
PFI-3 enhances iPSC reprogramming by inducing MET in fibroblasts, upregulating E-cadherin, and reducing ECM gene expression, including collagen.
Q4 2023Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration
Neurodegenerative diseases linked to Langerhans cell histiocytosis (LCH-ND) are caused by mutated myeloid cells compromising the blood-brain barrier, leading to inflammation and neuronal damage in the brain. Targeting MAPK activity and cell senescence reduces these effects and improves neurological outcomes.
Q4 2023The impact of short-lived controls on the interpretation of lifespan experiments and progress in geroscience
Reanalysis of lifespan studies shows that short-lived controls overstate longevity interventions' efficacy. The study suggests a mouse longevity intervention should only be considered with high confidence when control lifespans are close to 900 days or if the final lifespan of the treated group is considerably above 900 days.
Q4 2023