Regeneration leads to global tissue rejuvenation in aging sexual planarians
The research demonstrated that the sexually reproducing lineage of the planarian Schmidtea mediterranea, a freshwater species known for its remarkable regenerative capabilities, shows signs of aging. However, the process of amputation followed by regeneration reversed these aging signs, restoring youthful gene expression, stem cell states, tissue composition, and overall physiology. Findings suggest that planaria's natural age-reversal solution could offer valuable insights into anti-aging strategies for humans.
Q2 2023
Developmental mitochondrial Complex I activity determines lifespan
The timing of mitochondrial dysfunction plays a crucial role in disease pathology. Early-life mitochondrial impairment leads to a marked decrease in survival and stress resistance. Interestingly, adult flies with mitochondrial dysfunction lived longer and remained stress-resistant, despite having up to a 75% reduction in mitochondrial complex I activity. This suggests that the organism's adaptability to mitochondrial impairment is more flexible during adulthood, potentially opening new avenues in understanding and treating mitochondrial diseases.
Q2 2023
Cognitive Rejuvenation in Old Rats by Hippocampal OSKM Gene Therapy
The injection of Yamanaka genes (OSKM) into the hippocampus of old rats significantly improved their spatial learning performance and potentially their spatial memory. Morphological changes were not observed in astrocytes or mature neurons, indicating the treatment caused no harmful brain changes. The analysis of differential methylation suggested a possible rejuvenation effect on the old hippocampal methylome, extending evidence that viral vector-mediated delivery of Yamanaka genes in the brain can have regenerative effects.
Q2 2023
The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality – a prospective twin study
The study investigates the association between long-term leisure-time physical activity (LTPA), biological ageing, and mortality. It seeks to understand if LTPA patterns influence biological ageing and mortality, potentially mediating the beneficial relationship between LTPA and death from all causes. It also aims to account for reverse causality and genetic/environmental factors through prevalent disease accounting and a twin study design, as some suggest that LTPA may not prevent premature mortality, but reflect underlying good health.
Q2 2023
Effects of antidiabetic drugs on mortality risks in individuals with type 2 diabetes: A prospective cohort study of UK Biobank participants
This prospective study on a UK Biobank cohort reveals that among individuals with type 2 diabetes, those prescribed metformin or sodium glucose cotransporter 2 inhibitors (SGLT2I) have a higher survival probability compared to those using other anti-diabetic drugs. Remarkably, individuals on SGLT2I even showed increased survival compared to those without type 2 diabetes. Other anti-diabetic drugs either had a negative effect on lifespan or no significant impact.
Q2 2023
